Vol 7, Issue 335
REDD1 targets a phosphatase to the kinase Akt, thereby changing the substrate specificity of Akt and inhibiting mTORC1 activity.
- The membrane protein Pannexin1 forms two open-channel conformations depending on the mode of activation
Pannexin1 can be stimulated to form either a high- or a low-conductance channel with distinct ionic permeabilities.
Proteomics analysis of TGF-β signaling in keratinocytes reveals widespread changes in protein phosphorylation and abundance.
Retrograde flow of adherens junctions enables collectively migrating cells to maintain cohesion and requires polarized regulation of cadherin-catenin interactions.