Editors' ChoiceCell Cycle

Taking a Check on Chromosome Spacing

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Sci. Signal.  22 Jul 2014:
Vol. 7, Issue 335, pp. ec197
DOI: 10.1126/scisignal.2005706

Animal cells divide by mitosis. Chromosomes become condensed and congregate on the mitotic spindle in the center of the cell—the midzone. The spindle then separates sister chromosomes, pulling them to opposite ends of the cell, ready to form new daughter nuclei. Afonso et al. now show that chromosome separation is monitored by the level of midzone-associated Aurora B kinase activity (see the Perspective by Hadders and Lens). This process ensures that daughter nuclei only reassemble after sister chromosomes have successfully separated.

O. Afonso, I. Matos, A. J. Pereira, P. Aguiar, M. A. Lampson, H. Maiato, Feedback control of chromosome separation by a midzone Aurora B gradient. Science 345, 332–336 (2014). [Abstract] [Full Text]

M. A. Hadders, S. M. A. Lens, Mind the midzone. Science 345, 265–266 (2014). [Abstract] [Full Text]