PodcastImmunology

Science Signaling Podcast: 29 July 2014

See allHide authors and affiliations

Sci. Signal.  29 Jul 2014:
Vol. 7, Issue 336, pp. pc20
DOI: 10.1126/scisignal.2005675

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

This Podcast features an interview with Nicholas Gay, senior author of a Research Article that appears in the 29 July 2014 issue of Science Signaling, about an adaptor protein that is required for trafficking the pathogen-sensing receptor Toll-like receptor 4 (TLR4) to the cell surface. TLR4 becomes activated when it binds to an endotoxin that is present on Gram-negative bacteria. TLR4 signals from both the plasma membrane and endosomes to promote inflammation and the production of interferons, respectively. Liaunardy-Jopeace et al. report that the adaptor protein TMED7 is required for trafficking TLR4 to the plasma membrane. Blocking TMED7-mediated trafficking of TLR4 caused TLR4 to accumulate intracellularly and resulted in ligand-independent TLR4 signaling.

View Full Text