PodcastCancer

Science Signaling Podcast: 5 August 2014

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Sci. Signal.  05 Aug 2014:
Vol. 7, Issue 337, pp. pc21
DOI: 10.1126/scisignal.2005676

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Abstract

This Podcast features an interview with Juliane Mooz and Krishnaraj Rajalingam, authors of a Research Article that appears in the 5 August 2014 issue of Science Signaling, about the cellular functions of the kinase ARAF. RAF proteins are serine-threonine kinases that mediate signaling through the mitogen-activated protein kinase (MAPK) pathway, and aberrant RAF activity can transform normal cells into cancerous cells. There are three RAFs in mammals: ARAF, BRAF, and CRAF. The most studied of these is BRAF, mutations in which are associated with various cancers. Whereas the cellular functions of BRAF and CRAF have been extensively studied, not much is known about ARAF. Mooz et al. found that ARAF was required for the MAPK pathway activation and cell migration triggered by treating cancer cells with BRAF inhibitors.

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