Vol 7, Issue 338
- Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma
Targeting a kinase common to both the EGFR and TNFα signaling pathways may prevent drug resistance in glioblastoma.
Type IV collagen activates the cell surface receptor GPR126, an orphan receptor that is crucial for Schwann cell differentiation and myelination.
- The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice
A nonreceptor tyrosine kinase inhibits cytokine signaling to prevent the persistence of antibody-secreting cells.