Science Signaling Podcast: 12 August 2014

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Sci. Signal.  12 Aug 2014:
Vol. 7, Issue 338, pp. pc22
DOI: 10.1126/scisignal.2005746

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This Podcast features an interview with William Talbot, senior author of a Research Article that appears in the 12 August 2014 issue of Science Signaling, about the identification of a ligand for the orphan receptor GPR126. G protein–coupled receptors (GPCRs) are integral membrane proteins that, upon binding to extracellular ligands, activate intracellular G protein signaling pathways. GPCRs transduce signaling in diverse developmental, physiological, and behavioral processes, and aberrant GPCR signaling is implicated in many diseases. The ligands for many GPCRs have been identified, but the natural ligands that activate some GPCRs in vivo have not been identified. GPR126 is one of these orphan receptors, and it is involved in myelination of peripheral nerves and in development of the heart and inner ear. Paavola et al. identified type IV collagen as a ligand for GPR126 and identified the domains of GPR126 required for binding to this ligand.

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