PerspectiveLipid Rafts

Lipocalin 2 as a Membrane-Reorganizing Agent

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Sci. Signal.  12 Aug 2014:
Vol. 7, Issue 338, pp. pe19
DOI: 10.1126/scisignal.2005563

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Abstract

Lipocalins are a class of proteins that scavenge hydrophobic molecules in diverse contexts, including the immune system, the nervous system, and cancer. A recent study by Watanbe et al. identifies lipocalin 2 produced by the female mouse reproductive tract as a sperm-capacitating agent that alters the membrane properties of sperm in preparation for fertilization. The potential for lipocalins to act as general modulators of plasma membrane bioactivity is discussed.

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