Editors' ChoiceTuberculosis

TB Sunny Side Up

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Sci. Signal.  26 Aug 2014:
Vol. 7, Issue 340, pp. ec234
DOI: 10.1126/scisignal.2005821

Interleukin-32 (IL-32) could be a correlate of protection against tuberculosis. Montoya et al. report that IL-32 is a potential candidate marker of host defense against tuberculosis. Mycobacterium tuberculosis causes a sometimes deadly infection that nonetheless only develops to disease in about 10% of individuals. The authors performed gene expression profiles of human macrophages and found an association between IL-32 and the vitamin D antimicrobial pathway. Moreover, analysis of five different clinical data sets suggested that IL-32 can serve as a molecular marker of latent tuberculosis and may be activated in response to signaling by IL-15. These data suggest that IL-32 may not only serve as a putative correlate of protection but also contribute directly to host response to tuberculosis.

D. Montoya, M. S. Inkeles, P. T. Liu, S. Realegeno, R. M. B. Teles, P. Vaidya, M. A. Munoz, M. Schenk, W. R. Swindell, R. Chun, K. Zavala, M. Hewison, J. S. Adams, S. Horvath, M. Pellegrini, B. R. Bloom, R. L. Modlin, IL-32 is a molecular marker of a host defense network in human tuberculosis. Sci. Transl. Med. 6, 250ra114 (2014). [Abstract]