PodcastImmunology

Science Signaling Podcast: 26 August 2014

See allHide authors and affiliations

Science Signaling  26 Aug 2014:
Vol. 7, Issue 340, pp. pc24
DOI: 10.1126/scisignal.2005784

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

This Podcast features an interview with Alfred Singer, Gil Katz, and Leonid Pobezinsky, authors of a Research Article that appears in the 26 August 2014 issue of Science Signaling, about a microRNA that plays a role in the survival of T cells. During development in the thymus and after maturation and migration into the periphery, T cells require signaling through both the T cell receptor (TCR) and the interleukin-7 receptor (IL-7R) to survive. However, because sustained IL-7R signaling kills T cells, TCR signaling periodically inhibits IL-7R signaling to enable T cell survival. Katz et al. have identified a microRNA that is induced by T cell receptor activation and inhibits IL-7R signaling by reducing the abundance of Jak1, a kinase that transduces signaling downstream of IL-7R.

View Full Text