Editors' ChoiceStem Cells

Human Stem Cell Expansion

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Sci. Signal.  23 Sep 2014:
Vol. 7, Issue 344, pp. ec262
DOI: 10.1126/scisignal.2005924

Transfused blood saves lives. Despite the widespread use of this critical resource, it is difficult to increase blood cell numbers outside of the body. By screening thousands of small compounds, Fares et al. identified a molecule that expands human stem cell numbers in cord blood. The researchers generated many variations of that molecule and showed that one such compound provides even greater human blood cell expansion. If researchers can provide increased numbers of stem cells and progenitor cells, cord blood should find even greater use in the clinic.

I. Fares, J. Chagraoui, Y. Gareau, S. Gingras, R. Ruel, N. Mayotte, E. Csaszar, D. J. H. F. Knapp, P. Miller, M. Ngom, S. Imren, D.-C. Roy, K. L. Watts, H.-P. Kiem, R. Herrington, N. N. Iscove, R. K. Humphries, C. J. Eaves, S. Cohen, A. Marinier, P. W. Zandstra, G. Sauvageau, Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science 345, 1509–1512 (2014). [Abstract] [Full Text]