Editors' ChoiceNeuroscience

Making Dendritic Arbors During Development

Sci. Signal.  04 Nov 2014:
Vol. 7, Issue 350, pp. ec313
DOI: 10.1126/scisignal.aaa1987

Developing axons are known to compete for limiting, target-derived neurotrophins for survival and growth in the peripheral nervous system. Joo et al. suggest that an additional, reciprocal model is involved in the development of dendritic arbors of cerebellar Purkinje cells. Working in mice, the authors show that growing dendrites of Purkinje neurons require presynaptic partner-derived neurotrophins during competitive dendritic growth in the central nervous system.

W. Joo, S. Hippenmeyer, L. Luo, Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling. Science 346, 626–629 (2014). [Abstract] [Full Text]

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