By Alessia Perino, Martina Beretta, Ana Kilić, Alessandra Ghigo, Daniela Carnevale, Ivan Enrico Repetto, Laura Braccini, Dario Longo, Michaela Liebig-Gonglach, Tania Zaglia, Roberta Iacobucci, Marco Mongillo, Reinhard Wetzker, Michael Bauer, Silvio Aime, Alessandro Vercelli, Giuseppe Lembo, Alexander Pfeifer, Emilio Hirsch
Sci. Signal. : ra110 Full AccessRestricted Access
Blocking the activity of two PI3K isoforms in the brain may be a strategy for treating obesity.
By Viraj R. Sanghvi, Konstantinos J. Mavrakis, Joni Van der Meulen, Michael Boice, Andrew L. Wolfe, Mark Carty, Prathibha Mohan, Pieter Rondou, Nicholas D. Socci, Yves Benoit, Tom Taghon, Pieter Van Vlierberghe, Christina S. Leslie, Frank Speleman, Hans-Guido Wendel
Sci. Signal. : ra111 Full AccessRestricted Access
A set of microRNAs that target the Myb oncogene may function as tumor suppressors in T cell leukemia.
Online Cover This week features a Research Article that describes how molecular modeling, ligand docking analysis, and phylogenetics can reveal insight about the evolution of voltage-gated ion channels. The image shows a model of a two-pore channel with the positions of various ligands of calcium or sodium channels docked in the pore. [Image: Taufiq Rahman (Department of Pharmacology, Cambridge University, UK) and Sandip Patel (Department of Cell Developmental Biology, University College London, UK)]