PodcastNeuroscience

Science Signaling Podcast: 25 November 2014

See allHide authors and affiliations

Sci. Signal.  25 Nov 2014:
Vol. 7, Issue 353, pp. pc30
DOI: 10.1126/scisignal.aaa1326

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

This Podcast features an interview with Catherine Wasser and Joachim Herz, authors of a Research Article that appears in the 25 November 2014 issue of Science Signaling, about modifications to an apolipoprotein E receptor that affect synaptic plasticity and learning. Apolipoprotein E (ApoE) is a lipoprotein that helps transport fat-soluble molecules, such as cholesterol, around the body. In the brain, ApoE delivers cholesterol to neurons by binding to ApoE receptors, which triggers endocytosis of the cargo borne by the ApoE aggregates. ApoE receptors can also initiate intracellular signaling in response to binding to other ligands, such as Reelin. Signaling by the ApoE receptor Apoer2 controls neuronal migration during development, affects synaptic plasticity, and helps break down the β-amyloid plaques associated with Alzheimer's disease. Wasser et al. report that differential splicing and posttranslational modification of Apoer2 affects synaptic plasticity and learning in mice.

View Full Text