Editors' ChoiceCell Biology

Crosstalk Between Mitochondria and Mitosis

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Sci. Signal.  02 Dec 2014:
Vol. 7, Issue 354, pp. ec338
DOI: 10.1126/scisignal.aaa3745

Mitochondria, the power houses of the cell, contain their own genome. Nevertheless, the majority of their constituent proteins are encoded by nuclear genes and are translated in the cytosol. During the cell cycle, a cell needs to duplicate each of its constituent parts and organelles. Surprisingly, it has never been clear how or whether mitochondrial protein import is linked with the cell cycle. Harbauer et al. (see the Perspective by Schulz and Rehling) now show that one of the main conduits for mitochondrial protein import is directly regulated by phosphorylation during mitosis, and that this in turn promotes respiratory activity.

A. B. Harbauer, M. Opalińska, C. Gerbeth, J. S. Herman, S. Rao, B. Schönfisch, B. Guiard, O. Schmidt, N. Pfanner, C. Meisinger, Cell cycle–dependent regulation of mitochondrial preprotein translocase. Science 346, 1109–1113 (2014). [Abstract] [Full Text]

C. Schulz, P. Rehling, Powering the cell cycle. Science 346, 1059–1060 (2014). [Abstract] [Full Text]