Editors' ChoiceImmunology

A Two-Cell Collaboration for Inflammation

Science Signaling  09 Dec 2014:
Vol. 7, Issue 355, pp. ec344
DOI: 10.1126/scisignal.aaa4293

Immune cells called neutrophils are first responders to infection. Neutrophils move within and through blood vessels to get to sites of infection quickly. Sreeramkumar et al. found that mouse neutrophils rely on platelets to help find such sites. Neutrophils extended protrusions into blood vessels. When these protrusions came into contact with platelets, the neutrophils migrated into the surrounding tissue to carry out their inflammatory functions. Preventing these neutrophil-platelet interactions alleviated collateral inflammatory damage to tissues in several injury models in mice.

V. Sreeramkumar, J. M. Adrover, I. Ballesteros, M. I. Cuartero, J. Rossaint, I. Bilbao, M. Nácher, C. Pitaval, I. Radovanovic, Y. Fukui, R. P. McEver, M.-D. Filippi, I. Lizasoain, J. Ruiz-Cabello, A. Zarbock, M. A. Moro, A. Hidalgo, Neutrophils scan for activated platelets to initiate inflammation. Science 346, 1234–1238 (2014). [Abstract] [Full Text]