Contents

06 January 2015
Vol 8, Issue 358
  • Contents

    • Editorial Guide

      • 2014: Signaling Breakthroughs of the Year

        The year’s highlights include molecular and functional insights into innate immunity, host-microbe interactions, and cell death and new techniques to study cell signaling.

    • Research Articles

    • Podcast

    • Editors' Choice

      • Insulin Promotes Serotonin Uptake

        Trophoblasts of patients with gestational diabetes exhibit increased serotonin due to impaired processing and trafficking of the serotonin uptake transporter.

      • Guiding Axons with Two Slits

        Whereas one fragment of Slit signals through Robo, the other triggers PlexinA1 to mediate axon guidance in the developing brain.

      • Skin Infection Triggers Fat Responses

        The subcutaneous fat layer thickens during infection and stimulates adipocytes to secrete a protective peptide.

      • Cashing In with ATM

        Reducing ATM signaling is neuroprotective in cell and animal models of Huntington’s disease.

      • mTOR and Human Aging

        Elderly volunteers produce an enhanced immune response to an influenza vaccine when mTOR is inhibited.

About The Cover

Cover image expansion

Online Cover This week features the annual Signaling Breakthroughs of the Year, highlighting molecular and functional insights into innate immunity, host-microbe interactions, and cell death and new techniques to study cell signaling. The image is an artist's depiction of the microbiota on the mucus secreted by the goblet cells in the intestinal epithelium. [Image: Heather McDonald/Science Signaling]