Editors' ChoiceImmunology

mTOR and Human Aging

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Sci. Signal.  06 Jan 2015:
Vol. 8, Issue 358, pp. ec7
DOI: 10.1126/scisignal.aaa5830

Inhibition of mTOR (mechanistic target of rapamycin) signaling extends life span and delays the onset of aging-related diseases in all species studied to date. These findings suggest that the mTOR pathway promotes aging. To address whether inhibition of mTOR is beneficial in humans, Mannick et al. found that the mTOR inhibitor RAD001 improved immune function in elderly volunteers as assessed by their response to influenza vaccination. It remains to be determined whether mTOR inhibition improves additional aging-related conditions in humans.

J. B. Mannick, G. Del Giudice, M. Lattanzi, N. M. Valiante, J. Praestgaard, B. Huang, M. A. Lonetto, H. T. Maecker, J. Kovarik, S. Carson, D. J. Glass, L. B. Klickstein, mTOR inhibition improves immune function in the elderly. Sci. Transl. Med. 6, 268ra179 (2014). [Abstract]