FocusCell Biology

The mitotic checkpoint protein kinase BUB1 is an engine in the TGF-β signaling apparatus

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Sci. Signal.  13 Jan 2015:
Vol. 8, Issue 359, pp. fs1
DOI: 10.1126/scisignal.aaa4636

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Abstract

The transforming growth factor–β (TGF-β) pathway mediates critical events in cell behavior that contribute to development and disease. The mitotic checkpoint guarantees faithful chromosomal segregation during cell division. In the 6 January 2015 issue of Science Signaling, Nyati et al. reported that the mitotic checkpoint kinase BUB1 promotes the activity of TGF-β receptors, which adds new molecular links between these fundamental biological processes.

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