Contents
Vol 8, Issue 363
Contents
Research Articles
- Ski regulates Hippo and TAZ signaling to suppress breast cancer progression
Ski inhibits the transcriptional coactivator TAZ through Hippo pathway–dependent and Hippo pathway–independent mechanisms.
- Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides
Mechanosensitive Piezo channels involved in pain signaling need specific membrane phosphoinositides for activity.
- Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection
Signals produced by early responding cells to viral infection calibrate the immune response of the cell population.
Podcast
- Science Signaling Podcast: 10 February 2015
Ski inhibits activity of the transcriptional coactivator TAZ and breast cancer progression through multiple mechanisms.
Editors' Choice
- Finding the decretin hormone
Limostatin in flies (NMU in mammals) is the long-sought hormone that decreases insulin secretion.
- A role for Cl– in salt-sensitive hypertension
Altered intracellular Cl– underlies changes in salt-sensitive neuronal signaling to produce high blood pressure.
- Septins restrict polar growth
A regulator of G protein signaling has dual functions in the yeast response to mating pheromone.
- Exploring the limits of protein sequence space
Four key residues in the Escherichia coli protein kinase PhoQ drive recognition of its substrate PhoP.
- Bacterial infection breaks the lymph node barrier
Infection disrupts the organization of macrophages in the lymph node and impairs immunity to secondary infections.
Focus
- Spicing up the sensation of stretch: TRPV1 controls mechanosensitive Piezo channels
Phosphoinositide abundance regulates mechanosensitive Piezo channel activity.
