FocusNeuroscience

Spicing up the sensation of stretch: TRPV1 controls mechanosensitive Piezo channels

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Sci. Signal.  10 Feb 2015:
Vol. 8, Issue 363, pp. fs3
DOI: 10.1126/scisignal.aaa6769

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Abstract

Piezo proteins—a family of mammalian cation-selective ion channels that respond to mechanical stretch—are molecular mediators of biological processes, including vascular tone, hearing, touch, and pain. In this issue of Science Signaling, Rohacs and colleagues demonstrate that activation of the heat-sensitive transient receptor potential vanilloid 1 (TRPV1), another cation channel, inhibits Piezo channels through a calcium-induced depletion of phosphoinositides. This regulation could contribute to the cellular mechanisms by which the TRPV1 activator capsaicin mitigates mechanical hypersensitivity.

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