Recruitment of the adaptor protein Nck to PECAM-1 couples oxidative stress to canonical NF-κB signaling and inflammation

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Sci. Signal.  24 Feb 2015:
Vol. 8, Issue 365, pp. ra20
DOI: 10.1126/scisignal.2005648

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Preventing reperfusion injury after ischemia

Various pathological conditions, including atherosclerosis, can cause blood vessels to become blocked, leading to lack of oxygen (a condition called ischemia). When blood flow resumes (a process called reperfusion), reactive oxygen species are generated, which can trigger oxidative stress and inflammatory responses. Chen et al. found that the adaptor protein Nck linked the oxidative stress caused by reactive oxygen species to the activation of a signaling pathway that promotes inflammation in endothelial cells, which line blood vessels. A peptide that blocked the ability of Nck to interact with its binding partners decreased the signs of inflammation in mice subjected to an ischemia/reperfusion injury.