Editors' ChoiceImmunology

How the immune system readies for battle

Sci. Signal.  10 Mar 2015:
Vol. 8, Issue 367, pp. ec58
DOI: 10.1126/scisignal.aab0558

Although gene expression is tightly controlled at both the RNA and protein levels, the quantitative contribution of each step, especially during dynamic responses, remains largely unknown. Indeed, there has been much debate whether changes in RNA level contribute substantially to protein-level regulation. Jovanovic et al. built a genome-scale model of the temporal dynamics of differential protein expression during the stimulation of immunological dendritic cells (see the Perspective by Li and Biggin). Newly stimulated functions involved the up-regulation of specific RNAs and concomitant increases in the levels of the proteins they encode, whereas housekeeping functions were regulated posttranscriptionally at the protein level.

M. Jovanovic, M. S. Rooney, P. Mertins, D. Przybylski, N. Chevrier, R. Satija, E. H. Rodriguez, A. P. Fields, S. Schwartz, R. Raychowdhury, M. R. Mumbach, T. Eisenhaure, M. Rabani, D. Gennert, D. Lu, T. Delorey, J. S. Weissman, S. A. Carr, N. Hacohen, A. Regev, Dynamic profiling of the protein life cycle in response to pathogens. Science 347, 1259038 (2015). [Abstract] [Full Text]

J. J. Li, M. D. Biggin, Statistics requantitates the central dogma. Science 347, 1066­–1067 (2015). [Abstract] [Full Text]