PodcastStructural Biology

Science Signaling Podcast: 10 March 2015

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Sci. Signal.  10 Mar 2015:
Vol. 8, Issue 367, pp. pc6
DOI: 10.1126/scisignal.aaa9415

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Abstract

This Podcast features an interview with Richard Neutze, senior author of a Research Article that appears in the 10 March 2015 issue of Science Signaling, about a new structural study of the photoreceptor rhodopsin. Rhodopsin is a G protein–coupled receptor that is most abundant in the plasma membranes of rod cells of the retina, where it is important for vision in dim light. Light induces a conformational change in rhodopsin that triggers intracellular signaling through G proteins. Crystal structures of rhodopsin have revealed much of the fine structural details of the protein but do not show the structural changes induced by light. Malmerberg et al. used time-resolved wide angle X-ray scattering to study light-induced conformational changes in the structure of rhodopsin in a native membrane and in real time.

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