Editors' ChoiceDevelopmental Biology

Heart regeneration: Small cues from development

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Sci. Signal.  24 Mar 2015:
Vol. 8, Issue 369, pp. ec71
DOI: 10.1126/scisignal.aab1591

With limited ability to repair itself after injury, the mature heart may need to look to development for some lessons. By reactivating pathways that are present during mammalian development, it may be possible to encourage cardiac regeneration. In mice, Tian et al. found that the microRNA cluster mir302-367 stimulates cardiomyocyte proliferation during early heart development by inhibiting the Hippo pathway. Transient treatment with miR302-367 mimics promoted cardiac regeneration in mice after myocardial infarction, suggesting that such small RNAs can be harnessed therapeutically to repair the adult heart.

Y. Tian, Y. Liu, T. Wang, N. Zhou, J. Kong, L. Chen, M. Snitow, M. Morley, D. Li, N. Petrenko, S. Zhou, M. Lu, E. Gao, W. J. Koch, K. M. Stewart, E. E. Morrisey, A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci. Transl. Med. 7, 279ra38 (2015). [Abstract]

G. Tao, J. Wang, J. F. Martin, Small RNA: From development to regeneration. Sci. Transl. Med. 7, 279fs12 (2015). [Abstract]