31 March 2015
Vol 8, Issue 370

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that the anesthetic ketamine binds to a subset of mouse olfactory receptors, which are GPCRs. Structural analysis identified receptor residues that formed a ketamine-binding site, and mutation of nonresponding receptors to engineer the ketamine-binding site rendered the receptors reponsive to ketamine. The image shows a model of the binding of ketamine (yellow) to a responsive olfactory receptor. [Image: Jose Manuel Perez-Aguilar, Department of Physiology and Biophysics, Weill Cornell Medical College, NY, USA]