FocusCOMPUTATIONAL BIOLOGY

Good practices for building dynamical models in systems biology

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Sci. Signal.  07 Apr 2015:
Vol. 8, Issue 371, pp. fs8
DOI: 10.1126/scisignal.aab0880

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Abstract

Dynamic models can offer deep understanding of information processing mechanisms in physiology, cell signaling, and biological regulation when they are appropriately detailed. Here, we describe some of the key aspects of the model-building process, including proper parameterization and error analysis, as well as common mistakes, such as model-tweaking and oversimplification, which can decrease the value of the models.

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