Research ArticlePhysiology

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

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Sci. Signal.  14 Apr 2015:
Vol. 8, Issue 372, pp. ra34
DOI: 10.1126/scisignal.aaa5903

Article Information

vol. 8 no. 372 ra34

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History: 
  • Received January 5, 2015
  • Accepted March 4, 2015

Author Information

  1. Jacky Chung1,
  2. Daniel E. Bauer2,3,
  3. Alireza Ghamari2,3,
  4. Christopher P. Nizzi4,
  5. Kathryn M. Deck4,
  6. Paul D. Kingsley5,
  7. Yvette Y. Yien1,
  8. Nicholas C. Huston1,
  9. Caiyong Chen1,*,
  10. Iman J. Schultz1,,
  11. Arthur J. Dalton1,
  12. Johannes G. Wittig1,,
  13. James Palis5,
  14. Stuart H. Orkin2,3,
  15. Harvey F. Lodish6,
  16. Richard S. Eisenstein4,
  17. Alan B. Cantor2,3, and
  18. Barry H. Paw1,2,3,§
  1. 1Division of Hematology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Division of Hematology-Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
  5. 5Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA.
  6. 6Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  1. §Corresponding author. E-mail: bpaw{at}rics.bwh.harvard.edu
    • * Present address: Zhejiang University, Hangzhou 310058, China.

    • Present address: InteRNA Technologies, 3584 CH Utrecht, Netherlands.

    • Present address: Technische Universität Dresden, BIOTEChnologisches Zentrum, Dresden 01307, Germany.

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