PodcastCardiac Physiology

Science Signaling Podcast: 21 April 2015

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Sci. Signal.  21 Apr 2015:
Vol. 8, Issue 373, pp. pc10
DOI: 10.1126/scisignal.aab2834

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Abstract

This Podcast features an interview with Gerald W. Dorn II and Moshi Song, authors of a Research Article that appears in the 21 April 2015 issue of Science Signaling, about how two related isoforms of protein kinase C (PKC) control growth of the heart in both developmental and pathological contexts. There are several isoforms of PKC, and these participate in many different signaling pathways that control diverse cellular processes. Based on how they are activated, PKCs are categorized into three groups: conventional, novel, and atypical. PKCδ and PKCε are closely related novel PKCs that have partially redundant functions in the heart. By removing both PKCδ and PKCε from cardiomyocytes, Song et al. found that these two related PKC isoforms normally limit heart growth both during development and in adult mice. Embryos lacking both PKCδ and PKCε had enlarged hearts, and adults lacking both PKCδ and PKCε exhibited greater cardiac hypertrophy in response to pressure overload. These results have implications for the clinical use of PKC inhibitors to treat cardiac disease and other diseases, such as cancer.

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