Science Signaling Podcast: 5 May 2015

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Sci. Signal.  05 May 2015:
Vol. 8, Issue 375, pp. pc11
DOI: 10.1126/scisignal.aab3889

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This Podcast features an interview with James Martin, primary author of a Research Article that appears in the 5 May 2015 issue of Science Signaling, about how reducing Hippo signaling might improve the ability of the heart to regenerate. The kinase Hippo prevents overgrowth of the heart during embryonic development by suppressing activity of the transcriptional coactivator Yap, which promotes expression of genes required for cell proliferation. Although Hippo signaling is important during development to keep the heart from growing too much, it limits the ability of the heart to regenerate in mature animals. Morikawa et al. found that, in addition to promoting the expression of genes that drive cell proliferation, Yap also promoted the expression of genes important for cytoskeletal remodeling in cardiomyocytes. Compared to cardiomyocytes from control animals, cardiomyocytes from mice lacking Hippo signaling exhibited enhanced migratory properties in vitro and migrated toward sites of injury in vivo. These findings suggest that inhibiting Hippo signaling might be beneficial for promoting healing in damaged hearts.

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