Editors' ChoicePREGNANCY

Drugs may play a PPARt against preeclampsia

Sci. Signal.  09 Jun 2015:
Vol. 8, Issue 380, pp. ec154
DOI: 10.1126/scisignal.aac7360

Preeclampsia is a vascular disorder of pregnancy, with symptoms including hypertension and loss of protein in the urine. The underlying causes of preeclampsia are not yet understood, and the only effective treatment is preterm delivery of the infant, which poses many risks for the child. Holobotovskyy et al. determined that regulator of G protein signaling 5 (RGS5) plays an important role in the regulation of blood pressure during pregnancy and that lack of this protein causes a preeclampsia-like syndrome in mouse models. These mice could be effectively treated with drugs called PPAR agonists, some of which are already approved for diabetes in humans, suggesting a potential therapeutic approach for preeclampsia.

V. Holobotovskyy, Y. S. Chong, J. Burchell, B. He, M. Phillips, L. Leader, T. V. Murphy, S. L. Sandow, D. J. McKitrick, A. K. Charles, M. Tare, L. F. Arnolda, R. Ganss, Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia. Sci. Transl. Med. 7, 290ra88 (2015). [Abstract]