Vol 8, Issue 382
Epigenetically mediated changes in postsynaptic glutamate receptor expression enable neurons to adjust responsiveness to their environment.
- IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions
The kinase activity of IRE1 prevents cell death triggered by permeabilization of the ER by Bax and Bak.
- Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners
Finding compounds that target a specific phosphatase-substrate interaction may yield immunosuppressive drugs with fewer side effects.