Editors' ChoiceCardiac Physiology

Making cardiomyocytes

Sci. Signal.  30 Jun 2015:
Vol. 8, Issue 383, pp. ec180
DOI: 10.1126/scisignal.aac8729

In the heart, multiple cell types work together. Cardiac progenitor cells give rise to cardiomyocyte, endothelial, or smooth muscle lineages. However, the identity of a marker specific to cardiomyocyte formation has been elusive. Jain et al. now identify a specialized progenitor population that is committed exclusively to forming cardiomyocytes. They also identify the niche signals that promote lineage commitment and the mechanisms involved in making cardiomyocytes. The findings may help in the development of future cell-based regenerative therapeutics for heart disease.

R. Jain, D. Li, M. Gupta, L. J. Manderfield, J. L. Ifkovits, Q. Wang, F. Liu, Y. Liu, A. Poleshko, A. Padmanabhan, J. C. Raum, L. Li, E. E. Morrisey, M. M. Lu, K.-J. Won, J. A. Epstein, Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science 348, aaa6071 (2015). [Abstract] [Full Text]