07 July 2015
Vol 8, Issue 384
  • Contents

    • Research Articles

    • Research Resource

    • Review

    • Podcast

      • Science Signaling Podcast: 7 July 2015

        A secreted protein that controls synaptic plasticity protects neurons from the toxic effects of amyloid β.

    • Editors' Choice

      • A pro-memory prion protein

        Neuronal activity stimulates the deSUMOylation and aggregation of CPEB3, which promotes memory formation and maintenance.

      • Constraining regulatory T cells

        A receptor for the lipid lysophosphatidylserine reduces regulatory T cell function during inflammation to promote immune responses.

      • Sleep cyclin

        The transcriptional cofactor Taranis promotes sleep by decreasing the abundance of CycA and inhibiting Cdk1.

      • Clearing out selenoprotein garbage

        A surveillance system recognizes and degrades truncated proteins that fail to incorporate a specific amino acid.

      • Two hits in viral cardiomyopathy

        Enterovirus-derived C-terminal dystrophin fragment is a dominant-negative peptide representing a new therapeutic target for viral cardiomyopathy remediation.

      • B cell receptor signaling dynamics

        Quantitative mass spectrometry–based proteomics analysis reveals the phosphorylation and ubiquitylation dynamics of B cell receptor complexes.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes how a protein modification called S-nitrosylation controls the brain's use of glutamate for energy or neurotransmission. The image shows a molecular model of S-nitrosylated glutamine synthetase, an enzyme that generates glutamine from glutamate. [Image: Kim A. Sharp/University of Pennsylvania]