PodcastNeurodegeneration

Science Signaling Podcast: 7 July 2015

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Sci. Signal.  07 Jul 2015:
Vol. 8, Issue 384, pp. pc17
DOI: 10.1126/scisignal.aac8470

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Abstract

This Podcast features an interview with Courtney Lane-Donovan and Joachim Herz, authors of a Research Article that appears in the 7 July 2015 issue of Science Signaling, about how the secreted protein Reelin helps protect neurons from the toxicity of amyloid β. Amyloid β is a fragment of the amyloid precursor protein that aggregates inside cells and is a major component of the amyloid plaques that characterize Alzheimer's disease. Amyloid plaques are toxic to neurons, so their presence causes neurodegeneration, which can affect learning and memory. Lane-Donovan et al. found that a secreted protein called Reelin normally helps protect the brain from the neurotoxic buildup of amyloid β by maintaining synaptic plasticity.

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