Editors' ChoiceImmunology

Single-cell measurements map immunity

Sci. Signal.  14 Jul 2015:
Vol. 8, Issue 385, pp. ec192
DOI: 10.1126/scisignal.aac9930

Multiple characteristics of individual cells define cell types and their physiological states. Spitzer et al. quantitated the abundance of 39 different cell surface proteins or transcription factors on individual cells of the mouse immune system. They used these measurements to create a map that clustered similar individual cells into groups corresponding to cell type and function. Their extensible experimental platform will allow the inclusion of other data types and data from independent laboratories.

M. H. Spitzer, P. F. Gherardini, G. K. Fragiadakis, N. Bhattacharya, R. T. Yuan, A. N. Hotson, R. Finck, Y. Carmi, E. R. Zunder, W. J. Fantl, S. C. Bendall, E. G. Engleman, G. P. Nolan, An interactive reference framework for modeling a dynamic immune system. Science 349, 1259425 (2015). [Abstract] [Full Text]