PodcastMetabolism

Science Signaling Podcast: 21 July 2015

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Sci. Signal.  21 Jul 2015:
Vol. 8, Issue 386, pp. pc18
DOI: 10.1126/scisignal.aac9669

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Abstract

This Podcast features an interview with Cristina Murga and Rocio Vila-Bedmar, authors of a Research Article that appears in the 21 July 2015 issue of Science Signaling, about how deleting the kinase GRK2 can counteract some of the metabolic effects of a bad diet. Obesity affects many of the body's normal functions, most notably metabolism. Obesity is associated with insulin resistance and reduced glucose tolerance, which can lead to type 2 diabetes. It also promotes hepatic steatosis, the accumulation of fat in the liver. Vila-Bedmar et al. show that deleting GRK2 can prevent further weight gain and hepatic steatosis and improve glucose sensitivity in obese mice. Deleting GRK2 improved these metabolic consequences of high-fat diet–induced obesity even if the kinase was deleted after the mice had already become obese and resistant to insulin.

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