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Science Signaling Podcast: 28 July 2015

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Sci. Signal.  28 Jul 2015:
Vol. 8, Issue 387, pp. pc19
DOI: 10.1126/scisignal.aad0016

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Abstract

This Podcast features an interview with Pooja Desai, author of a Research Article that appears in the 28 July 2015 issue of Science Signaling, about distinct calcium channel pore subunits that are produced from the same transcript but mediate different types of calcium currents. Orai proteins form the pores of both calcium-release–activated calcium (CRAC) channels and arachidonic acid–regulated calcium (ARC) channels. Whereas CRAC channels allow calcium to flow into a cell when intracellular stores of calcium have been depleted, ARC channels allow calcium to flow into cells in response to proinflammatory lipids such as arachidonic acid and leukotriene C4. In mammals, Orai1 encodes not one but two different calcium channel subunits because the transcript has two different translation start sites. Desai et al. report that the short and long forms of Orai1 contribute to calcium channels with distinct properties and mediate different types of calcium currents.

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