04 August 2015
Vol 8, Issue 388

About The Cover

Cover image expansion

Online Cover This week features a Research Article that characterizes the relative contributions of the kinases ASK1 and ASK2 to host responses to viruses, such as influenza virus. Whereas both ASK1 and ASK2 mediated apoptosis in virus-infected cells, ASK1 alone mediated the production of the antiviral cytokine type I interferon. Thus, the relative abundance of ASK1 and ASK2 in cells determines the type of response elicited by viral infection. The image shows swine influenza virus particles (yellow) and a host cell. [Image: Dr. Klaus Boller/Science Source]