PodcastVASCULAR BIOLOGY

Science Signaling Podcast: 11 August 2015

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Sci. Signal.  11 Aug 2015:
Vol. 8, Issue 389, pp. pc20
DOI: 10.1126/scisignal.aad1081

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Abstract

This Podcast features an interview with Timothy Hla, author of a Research Article that appears in the 11 August 2015 issue of Science Signaling, about biased signaling by the lipid sphingosine 1-phosphate (S1P). Because it is not water-soluble, S1P circulates in complex with a protein chaperone, such as albumin or the high-density lipoprotein (HDL) component ApoM. Galvani et al. found that S1P elicited different signaling outcomes in vascular endothelial cells depending on whether it was bound to albumin or ApoM+HDL. S1P inhibited inflammation in cultured vascular endothelial cells when it was bound to ApoM+HDL, and S1P signaling suppressed atherosclerosis in mice. These observations suggest that, in addition to removing the excess cholesterol that promotes formation of atherosclerotic plaques, HDL may also promote vascular health by inhibiting the inflammation that contributes to plaque formation.

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