Research ArticleVASCULAR BIOLOGY

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation

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Sci. Signal.  11 Aug 2015:
Vol. 8, Issue 389, pp. ra79
DOI: 10.1126/scisignal.aaa2581

Article Information

vol. 8 no. 389 ra79

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History: 
  • Received November 7, 2014
  • Accepted July 15, 2015

Author Information

  1. Sylvain Galvani1,
  2. Marie Sanson1,
  3. Victoria A. Blaho1,
  4. Steven L. Swendeman1,
  5. Hideru Obinata1,*,
  6. Heather Conger2,
  7. Björn Dahlbäck3,
  8. Mari Kono4,
  9. Richard L. Proia4,
  10. Jonathan D. Smith2, and
  11. Timothy Hla1,
  1. 1Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.
  2. 2Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA.
  3. 3Department of Translational Medicine, Skåne University Hospital, Lund University, 214 28 Malmö, Sweden.
  4. 4Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  1. Corresponding author. E-mail: tih2002{at}med.cornell.edu
    • * Present address: Gunma University, Gunma, 371-8510 Japan.

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