Science Signaling Podcast for 8 September 2015: Ubiquitin ligase RNF43 in Wnt signaling

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Sci. Signal.  08 Sep 2015:
Vol. 8, Issue 393, pp. pc22
DOI: 10.1126/scisignal.aad2744

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This Podcast features an interview with Markus Gerhard, author of a Research Article that appears in the 8 September 2015 issue of Science Signaling, about the role of the E3 ubiquitin ligase RNF43 in Wnt signaling. Ubiquitylation is a posttranslational modification that regulates the stability, subcellular localization, or activity of proteins. E3 ubiquitin ligases are enzymes that transfer ubiquitin groups to appropriate targets. RNF43 is an E3 ubiquitin ligase that inhibits Wnt signaling, aberrant activation of which is important in the development and progression of colorectal cancer. Loregger at al. found that RNF43 inhibits Wnt signaling in the nucleus by sequestering TCF4, a transcription factor that mediates the expression of Wnt target genes.

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