PodcastVascular Disease

Science Signaling Podcast for 8 September 2015: Turning macrophages into foam cells

Sci. Signal.  08 Sep 2015:
Vol. 8, Issue 393, pp. pc23
DOI: 10.1126/scisignal.aad2897

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Abstract

This Podcast features an interview with Roy L. Silverstein, author of a Research Article that appears in the 8 September 2015 issue of Science Signaling, about signaling events in macrophages the lead to the formation of the foam cells that are associated with atherosclerotic plaques. Under certain conditions, low-density lipoproteins (LDL) penetrate the arterial endothelium and become oxidized. Oxidized LDL is taken up by macrophages, which become overloaded with lipids and are then referred to as foam cells. The macrophage cell surface receptor CD36 binds to and mediates the internalization of oxidized LDL. Chen et al. found that the Na+/K+-ATPase is important for CD36-mediated uptake of oxidized LDL by macrophages. Macrophages that lacked activity of this ion transporter showed reduced uptake of oxidized LDL and protected mice from developing atherosclerosis in response to a high-fat diet.

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