FocusDevelopmental Biology

Genetic evidence for a Smoothened-Gαi signaling axis in mammals

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Sci. Signal.  15 Sep 2015:
Vol. 8, Issue 394, pp. fs16
DOI: 10.1126/scisignal.aad0353

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Abstract

In this issue of Science Signaling, Villanueva et al. report on the identification of heterotrimeric guanine nucleotide–binding protein (G protein) Gαi2 as an essential effector of Smoothened-mediated mammary epithelial cell proliferation. Through a series of in vivo experiments, the authors delineate a Smoothened-regulated Gli-independent Gαi signal that provides direct genetic evidence connecting Smoothened with Gαi in mice.

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