PodcastImmunology

Science Signaling Podcast for 29 September 2015: Glutamine and T cell differentiation

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Sci. Signal.  29 Sep 2015:
Vol. 8, Issue 396, pp. pc25
DOI: 10.1126/scisignal.aad4231

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Abstract

This Podcast features an interview with Naomi Taylor and Valérie Dardalhon, authors of a Research Article that appears in the 29 September 2015 issue of Science Signaling, about how availability of the nutrient glutamine affects the differentiation of T cells. Upon activation, naïve CD4+ T cells proliferate and differentiate into several distinct subtypes. These subtypes of T cells differ from one another in the cytokines that they secrete, and they have different functions during the immune response. Whereas effector T cells, such as T helper 1 (TH1) cells, promote the immune response, regulatory T (Treg) cells restrain T cell responses to ensure that the immune response does not get out of control. Klysz et al. found that extracellular glutamine was important for the differentiation of TH1 cells, but not for Treg cells. These findings suggest that the reduced availability of glutamine in the tumor microenvironment may suppress the immune response by favoring the production of Tregs at the expense of TH1 cells.

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