FocusPhysiology

Putting it all on pigmentation: Heuristics of a bold and stochastic cell fate decision

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Sci. Signal.  06 Oct 2015:
Vol. 8, Issue 397, pp. fs17
DOI: 10.1126/scisignal.aad2816

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Abstract

Gradients of transmembrane potential coordinate cell-fate decisions and patterning during embryogenesis and wound-healing. Bioelectrical signaling may also be more important for adult pathologies than currently recognized. In this issue of Science Signaling, Lobikin et al. describe a role for bioelectric signals during the development of Xenopus leavis embryos to instruct an organism-level response reminiscent of neoplastic progression in melanoma.

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