FocusCancer

Proteostasis trumps YAP in colon cancer

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Sci. Signal.  06 Oct 2015:
Vol. 8, Issue 397, pp. fs18
DOI: 10.1126/scisignal.aad3123

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Abstract

In this issue of Science Signaling, Zhang et al. find a new role for verteporfin in the control of colorectal cancer progression through the selective induction of proteotoxicity rather than through inhibition of the transcription cofactor YAP. The study further documents the potential strategy of targeting proteostasis to kill cancer cells.

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