PodcastImmunology

Science Signaling Podcast for 6 October 2015: Hippo signaling in T cells

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Sci. Signal.  06 Oct 2015:
Vol. 8, Issue 397, pp. pc26
DOI: 10.1126/scisignal.aad4366

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Abstract

This Podcast features an interview with Fengyuan Tang, author of a Research Article that appears in the 6 October 2015 issue of Science Signaling, about how Hippo signaling is transduced in T cells. The mammalian Hippo homolog MST1 regulates cell proliferation and tissue growth by activating the kinase LATS, which in turn inhibits the transcriptional coactivator YAP. MST1 is also important for regulating the trafficking of T cells in the immune system, but LATS and YAP are not required for signaling in this context. Tang et al. found that the kinases NDR1 and NDR2, which are closely related to LATS, were required for MST1-dependent egress of thymocytes from the thymus.

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