Editors' ChoiceCell death

Dying to impress the immune system

Sci. Signal.  20 Oct 2015:
Vol. 8, Issue 399, pp. ec301
DOI: 10.1126/scisignal.aad6480

Besides reacting to microbes, T cells can also mount immune responses to fragments of dying cells, which they encounter displayed on dendritic cells. Not all dying cells activate T cells, however, so what differentiates the dying cells that do? Yatim et al. studied two forms of programmed cell death: apoptosis and necroptosis. Using mouse cells in culture and mouse models of inflammatory cell death and antitumor immunity, they found that programmed cell death initiated T cell immunity only when the dying cells signaled through the enzyme RIPK1 and the transcription factor NF-κB.

N. Yatim, H. Jusforgues-Saklani, S. Orozco, O. Schulz, R. Barreira da Silva, C. Reis e Sousa, D. R. Green, A. Oberst, M. L. Albert, RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8+ T cells. Science 350, 328–334 (2015). [Abstract] [Full Text]