Changes over time build neuronal diversity

Sci. Signal.  20 Oct 2015:
Vol. 8, Issue 399, pp. ec303
DOI: 10.1126/scisignal.aad6483

Although neural progenitors can keep generating new neurons, they can generate different neurons as the organism develops. Two different sections of the Drosophila brain, the mushroom bodies and the antennal lobes, show this characteristic, although the antennal lobes produce more different types of neurons over development than do the mushroom bodies. Liu et al. identified two RNA-binding proteins that manage this change over development in both settings.

Z. Liu, C.-P. Yang, K. Sugino, C.-C. Fu, L.-Y. Liu, X. Yao, L. P. Lee, T. Lee, Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates. Science 350, 317–320 (2015). [Abstract] [Full Text]