Editors' ChoicePharmacology

A new peptide for treating retinal disease

Sci. Signal.  20 Oct 2015:
Vol. 8, Issue 399, pp. ec306
DOI: 10.1126/scisignal.aad6448

Sidman et al. report the inhibitory effect of a peptide drug called Vasotide on blood vessel overgrowth in the retinas of three animal models of human blinding retinal diseases. Delivery of Vasotide in eye drops prevented a blood vessel growth-promoting molecule, VEGF, from binding to two different receptors, VEGFR-1 and neuropilin-1, present on the retinal endothelial cells that line the inner surface of blood vessels.

R. L. Sidman, J. Li, M. Lawrence, W. Hu, G. F. Musso, R. J. Giordano, M. Cardó-Vila, R. Pasqualini, W. Arap, The peptidomimetic Vasotide targets two retinal VEGF receptors and reduces pathological angiogenesis in murine and nonhuman primate models of retinal disease. Sci. Transl. Med. 7, 309ra165 (2015). [Abstract]

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